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Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), as well as neutral endopeptidase 24.11 (NEP 24.11) and renal clearance, resulting in a half-life of approximately 2 minutes

In the United States, the Centers for Disease Control and Prevention (CDC) reports that over 38.4 million individuals, approximately 11.6% of the population, are currently living with diabetes [2]

A recent CVOT meta-analysis showed that the magnitude of HbA1c reduction was correlated with retinopathy risk and was not associated with GLP-1RA treatment per se (50)

Lipid improvements typically become apparent within 12-20 weeks of initiating therapy, paralleling weight loss trajectory

GLP-1 plays an important role in how the body handles food after eating